Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 61, Issue 12, Pages 1455-1474Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-004-3466-8
Keywords
peptide deformylase; aminopeptidase; drug; metal cation; metalloprotease; human pathogenesis; therapeutics
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N-terminal methionine excision (NME) is the major proteolytic pathway responsible for the diversity of N-terminal amino acids in proteins. Dedicated NME components have been identified in all organisms, in all compartments in which protein synthesis occurs: cytoplasm, plastids and mitochondria. Recent studies have revealed that NME is regulated at various levels and plays an important role in controlling protein turnover. NME is essential in Eubacteria and lower eukaryotes and is the target of many natural and synthetic inhibitors. Such inhibitors have considerable potential for use in the treatment of various human diseases, from cancer to bacterial and parasitic infections.
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