Journal
ACCOUNTS OF CHEMICAL RESEARCH
Volume 37, Issue 6, Pages 379-386Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ar030171j
Keywords
-
Categories
Ask authors/readers for more resources
Two mechanisms of the interconversion of NADH and NAD(+) in the coenzyme itself and in its analogues are discussed: a one-step hydride transfer and a stepwise electron-proton-electron transfer. Direct characterization of the transient species in the stepwise process and inversion of the stability order of the keto and enol tautomers is presented. The nonenzymatic and enzyme-mediated reactions of selected pyridinium salts that affect the NADH reversible arrow NAD(+) equilibrium are discussed in terms of their potential cytotoxicity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available