Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 16, Issue 3, Pages 367-373Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2004.03.012
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Funding
- NCI NIH HHS [CA81140, CA09120] Funding Source: Medline
- NICHD NIH HHS [HD37091] Funding Source: Medline
- NIGMS NIH HHS [GM08042] Funding Source: Medline
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Members of the protein kinase C (PKC) family play important but distinct roles in B-cell activation, as demonstrated by emerging genetic and biochemical studies. PKCbeta is indispensable for B-cell antigen receptor (BCR)-induced NF-kappaB activation and B-cell survival. Recent evidence indicates that PKCbeta might regulate inhibitor of kappaB kinase (IKK) and NF-kappaB activation through interaction with the CARMA1/Bcl10/MALT signaling complex in BCR microdomains. By contrast, the novel PKC isoform PKCdelta is specifically required to maintain the tolerance of self-reactive B cells.
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