Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 34, Issue 6, Pages 1673-1679Publisher
WILEY
DOI: 10.1002/eji.200425089
Keywords
NK cell; KIR receptors; KIR3DL2; tetramers; EBV
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The recognition of MHC class I molecules by killer cell immunoglobulin-like receptors (KIR) is central to the control of NK cell function and can also modulate the CTL activation threshold. Among KIR receptors, KIR3DL2 is thought to interact with HLA-A3 and -A11, although direct evidence has been lacking. In this study, we show that HLA-A3 and -A11 tetramers specifically bind to KIR3DL2*001 transfectants and that this recognition is peptide-specific. Single amino acid substitutions in the nonamer peptide underline a critical role for residue 8 in recognition of KIR3DL2. However, the role of this interaction in vivo still remains to be established.
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