Journal
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 125, Issue 6, Pages 417-420Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2004.02.007
Keywords
oxidative stress; inev-1; C. elegans; mutation
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Funding
- NIEHS NIH HHS [ES07784] Funding Source: Medline
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Reactive oxygen species (ROS) are generated in mitochondria and are thought to be important in aging, carcinogenesis, and the development of other pathologies. We now provide direct experimental evidence linking mitochondrial ROS generation to the induction of nuclear DNA damage and subsequent mutagenesis of a chromosomal gene. Specifically, we demonstrate that the mev-1 mutant of Caenorhabditis elegans has elevated levels of oxidative damage in its chromosomal DNA. This mutant was shown previously to overproduce ROS in its mitochondria. We also show that mutation frequencies were higher in the mev-1 mutant under hypoxia than in the wild type strain. By extension. these data imply that mitochondrially derived ROS mutate other genes, including tumor suppressor genes and oncogenes. We propose that this three-step process (mitochondrial ROS --> nuclear DNA damage --> mutation) contributes to aging and age-associated diseases. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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