Journal
EUROPEAN JOURNAL OF BIOCHEMISTRY
Volume 271, Issue 11, Pages 2050-2055Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1432-1033.2004.04133.x
Keywords
apoptosis; MAP-kinase; neurons; neuroprotection; programmed cell death; signal transduction; survival
Categories
Ask authors/readers for more resources
Extracellular signal regulated kinases 1 and 2 (ERK1/2) regulate cellular responses to a variety of extracellular stimuli. In the nervous system, ERK1/2 is critical for neuronal differentiation, plasticity and may also modulate neuronal survival. In this minireview, we present evidence that supports prosurvival activity of ERK1/2 in neurons. Several reports suggest that ERK1/2 mediates neuroprotective activity of extracellular factors, including neurotrophins. In addition, ERK1/2 is activated by neuronal injury. In damaged cells, ERK1/2 activation may act as a defensive mechanism that helps to compensate for the deleterious effects of a damaging insult. The emerging mechanisms of ERK1/2-mediated neuroprotection may involve transcriptional regulation and/or direct inhibition of cell death machinery.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available