Journal
JOURNAL OF ETHNOPHARMACOLOGY
Volume 92, Issue 2-3, Pages 147-162Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2004.02.012
Keywords
drug discovery; galanthamine; Galanthus worwonowii; Leucojum aestivum; Narcissus pseudonarcissus; Alzheimer's; poliomyelitis; Bulgaria; Caucasus mountains (Russia); clinical study
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In recent years, galanthamine isolated from several members of the Amaryllidaceae (Leucojum spp., Narcissus species, Galanthus spp.) has become an important therapeutic options used to slow down the process of neurological degeneration in Alzheimer's disease. This review traces aspects of the history of its development from little known observational studies in the Caucasus Mountains (Southern Russia), to the use of this drug in Eastern European countries (esp. Bulgaria) in the treatment of poliomyelitis and ultimately to the recent introduction onto Western markets in the treatment of Alzheimer's disease. Of note, little is known about the early history of the drug's development and the review also points to other gaps in our knowledge about the ethnopharmacology, pharmacology and clinical use of galanthamine. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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