Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 61, Issue 13, Pages 1596-1600Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-004-4133-9
Keywords
proteasome; proteolysis; ubiquitin-independent; ornithine decarboxylase; antizyme; I kappa B alpha; c-Jun
Categories
Ask authors/readers for more resources
The majority of proteasome substrates identified to date are marked for degradation by polyubiquitinylation. Exceptions to this principle, however, are well documented and can help us understand the process proteasomes use to recognize their substrates. Examples include ornithine decarboxylase, p21/Cip1, TCRalpha, IkappaBalpha, c-Jun, calmodulin and thymidylate synthase. Degradation of these proteins can be completely ubiquitin-independent or coexist with ubiquitin-dependent pathways. Uncoupling degradation from ubiquitin modification may reflect the evolutionary conservation of mechanisms optimized for highly specialized regulatory functions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available