Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 101, Issue 22, Pages 8384-8389Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0402140101
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Funding
- NCI NIH HHS [P01 CA095616, P20 CA096470, 5K08CA82241, P20CA96470, P01CA95616] Funding Source: Medline
- NHGRI NIH HHS [1R01HG02341, R01 HG002341] Funding Source: Medline
- NICHD NIH HHS [HD007466, T32 HD007466] Funding Source: Medline
- NINDS NIH HHS [5K08NS42737, K08 NS042737] Funding Source: Medline
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The astrocyte represents the most abundant yet least understood cell type of the CNS. Here, we use a stringent experimental strategy to molecularly define the astrocyte lineage by integrating microarray datasets across several in vitro model systems of astrocyte differentiation, primary astrocyte cultures, and various astrocyterich CNS structures. The intersection of astrocyte data sets, coupled with the application of nonastrocytic exclusion filters, yielded many astrocyte-specific genes possessing strikingly varied patterns of regional CNS expression. Annotation of these astrocyte-specific genes provides direct molecular documentation of the diverse physiological roles of the astrocyte lineage. This global perspective in the normal brain also provides a framework for how astrocytes may participate in the pathogenesis of common neurological disorders like Alzheimer's disease, Parkinson's disease, stroke, epilepsy, and primary brain tumors.
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