Journal
IUBMB LIFE
Volume 56, Issue 6, Pages 309-315Publisher
WILEY
DOI: 10.1080/10258140412331286937
Keywords
CO sensing; CO signal transduction; CooA; NPAS2
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O-2, NO, and CO are substrates, products, and/or modulators in many enzymatic reactions including O-2 respiration, denitrification, N-2 fixation, and methanogenesis. Over the last decade, O-2, NO, and CO have been reported to act as signaling molecules in the control of several distinct biological functions. Here, the heme-based mechanisms of CO sensing by the bacterial homodimeric CooA and the mammalian heterodimeric NPAS2-BMAL1 transcriptional factors are reviewed, and the signal transduction pathways are discussed.
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