Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 5, Issue 6, Pages 441-450Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1400
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Sprouty proteins are evolutionarily conserved inducible inhibitors of signalling by receptor tyrosine kinases. They have been implicated in negative-feedback interactions that impart spatial and temporal constraints to intracellular signals. The repressive function of Sprouty proteins targets several receptor-tyrosine-kinase-dependent signalling steps, indicating that their activities might have broader biological consequences than was initially anticipated.
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