Journal
TRENDS IN IMMUNOLOGY
Volume 25, Issue 6, Pages 306-314Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2004.04.002
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Funding
- NICHD NIH HHS [K12 HD 01487] Funding Source: Medline
- NINDS NIH HHS [K02 NS 045607] Funding Source: Medline
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Recent data suggest that CXCL12 and CXCR4 have parallel effects in the immune and nervous systems; they regulate cellular movement, proliferation, plasticity and survival of neurons and lymphocytes. Parallel reliance on CXCL12 might support coordinated homeostatic interactions between the nervous and immune systems but might also constitute a unique vulnerability to inflammatory processes, such as HIV-1 infection, that target CXCR4.
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