Journal
EUROPEAN JOURNAL OF CANCER
Volume 40, Issue 9, Pages 1314-1319Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2004.03.003
Keywords
multicentre study; fluconazole; itraconazole; treatment; cancer patients; oropharyngeal candidiasis
Categories
Ask authors/readers for more resources
Oropharyngeal candidiasis is a frequent infection in cancer patients who receive cytotoxic drugs. In this study, the efficacy, safety and tolerance of fluconazole and itraconazole were compared in non-neutropenic cancer patients with oropharyngeal candidiasis. Of 279 patients who were randomised between the two treatment groups, 252 patients were considered to be eligible (126 in each group). The clinical cure rate was 74% for fluconazole and 62% for itraconazole (P = 0.04, 95% Confidence Interval (Cl): 0.5-23.3%). The mycological cure rate was 80% for fluconazole and 68% for itraconazole (P = 0.03, 95% CI: 1.2-22.6%). The safety and tolerance profile of both drugs were comparable. This study has shown that in patients with cancer and oropharyngeal candidiasis, fluconazole has a significantly better clinical and mycological cure rate compared with itraconazole. (C) 2004 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available