Journal
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
Volume 20, Issue 3, Pages 210-216Publisher
MARY ANN LIEBERT INC PUBL
DOI: 10.1089/1080768041223602
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The aqueous penetration of the commercial preparations of the fluoroquinolone antibiotics ofloxacin, ciprofloxacin, levofloxacin, and gatifloxacin were compared following topical dosing in a rabbit model. Levofloxacin achieved the highest aqueous concentrations, with a mean aqueous level of 4.8014 mucg/mL (p = 0.002, p = 0.00002, p = 0.015.) Ofloxacin (2.5136 mucg/mL) and gatifloxacin (2.4817 mucg/mL) achieved statistically equal aqueous concentrations (p = 0.479). Ciprofloxacin reached the lowest levels in the aqueous humor (0.9616 mucg/mL, p = 0.00002, 0.00004, 0.008). Gatifloxacin alone achieved concentrations in excess of the MIC(90)s of gram-positive pathogens of concern.
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