Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 19, Issue 6, Pages 914-923Publisher
WILEY
DOI: 10.1359/JBMR.040132
Keywords
BMD; osteoporosis; complex segregation analysis; bivariate genetic model
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BMD is a primary predictor of osteoporotic fracture, and its genetic determination is still unclear. This study showed that the correlation between BMD at different skeletal sites is caused by an underlying genetic structure of common genetic effects. In addition to possible shared (pleiotropic) genetic and environmental effects, each of the BMD variables may also be determined by site-specific genetic factors.
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