Journal
TISSUE ANTIGENS
Volume 63, Issue 6, Pages 609-611Publisher
WILEY
DOI: 10.1111/j.0001-2815.2004.00231.x
Keywords
DQA1*0403N; HLA-DQA1 allele; SBT; TBSA
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Funding
- PHS HHS [R01 A1 49383] Funding Source: Medline
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We report a novel DQA1 allele (DQA1*0403N) identified during sequence-based HLA-DQA1 typing of a Kenyan population. The new allele is identical to DQA1*0401 at exon 2 except for a single-nucleotide substitution at codon 53, changing it from lysine to a stop codon (CAA-->TAA). The substitution at codon 53 was confirmed by sequencing two separate polymerase chain reaction products and by sequencing multiple clones obtained following TOPO-TA cloning. The resulting stop codon at position of codon 53 in exon 2 is predicted to produce a non-functional DQA1 alpha-chain. The new allele has been named by the WHO nomenclature committee as DQA1*0403N. This is the first report of a null allele detected in the DQA1 gene.
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