Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 10, Issue -, Pages S23-S30Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1191/1352458504ms1027oa
Keywords
axons; multiple sclerosis; myelin; oligodendrocytes; pathology
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The pathological hallmark of chronic multiple sclerosis includes focal demyelination, gliosis, inflammation and axonal injury. There is limited information on whether these pathological features differ across the clinical phenotypes of the disease (relapsing-remitting, secondary progressive, and primary progressive). This review will focus on the pathological aspects of PPMS and pathogenic implications. A better understanding of the differences in PPMS pathology and pathogenesis will lead to more effective treatment strategies.
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