Journal
PROSTATE
Volume 59, Issue 4, Pages 357-359Publisher
WILEY
DOI: 10.1002/pros.20005
Keywords
gene; serine protease; mutation; urologic cancer
Categories
Funding
- NCI NIH HHS [K05 CA 90754, R01 CA 56678, R01 CA 78836, R01 CA 82664] Funding Source: Medline
Ask authors/readers for more resources
BACKGROUND. Serine proteases play an important role in prostate cancer (PCa) invasion through the degradation of extracellular matrix proteins and interaction with growth modulating factors. The transmembrane serine protease 2 (TMPRSS2) gene encodes a type II transmembrane protein which, due to its cell surface localization, could be a potentially useful predictive marker for PCa. METHODS. We screened a population of 24 unrelated individuals for sequence variants in the TMPRSS2 gene, and found a Met160Val change in 33%. We then tested 559 cases and 523 controls from a population-based case-control study of middle-aged men from Washington State. RESULTS. Men with the GG genotype and a first-degree family history of PCa had a significantly higher risk for PCa relative to men without a family history (OR = 2.05; 95% CI = 1.3-3.2). However, the interaction between genotype and family history of PCa was not significant (P = 0.52). CONCLUSIONS. Larger, more detailed studies are needed to fully investigate the role of serine proteases in PCa. (C) 2003 Wiley-Liss, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available