Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 16, Issue 3, Pages 293-299Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2004.03.003
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Nonsense-mediated mRNA decay is a surveillance pathway that reduces errors in gene expression by eliminating aberrant mRNAs that encode incomplete polypeptides. Recent experiments suggest a working model whereby premature and normal translation termination events are distinct as a consequence of the spatial relationship between the termination codon and mRNA binding proteins, a relationship partially established by nuclear pre-mRNA processing. Aberrant termination then leads to both translational repression and an increased susceptibility of the mRNA to multiple ribonucleases.
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