Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 5, Issue 6, Pages 451-463Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1403
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Riboswitches are complex folded RNA domains that serve as receptors for specific metabolites. These domains are found in the non-coding portions of various mRNAs, where they control gene expression by harnessing allosteric structural changes that are brought about by metabolite binding. New findings indicate that riboswitches are robust genetic elements that are involved in regulating fundamental metabolic processes in many organisms.
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