Journal
AQUACULTURE
Volume 317, Issue 1-4, Pages 53-57Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aquaculture.2011.04.038
Keywords
Quorum sensing; Micro-algae; Quorum sensing interference; Luminescent vibrios
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Funding
- University Putra Malaysia (UPM)
- Malaysian Ministry of Higher Education
- FWO-Vlaanderen
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Quorum sensing, bacterial cell-to-cell communication with small signal molecules such as acyl-homoserine lactones, regulates the virulence of many pathogenic bacteria. Therefore, interfering with quorum sensing is currently being explored as a novel biocontrol strategy to fight bacterial infections. In this study, the effects of 19 micro-algal strains on acyl-homoserine lactone-regulated phenotypes of three reporter strains were investigated. Two freshwater micro-algae inhibited violacein production of quorum sensing reporter strain Chromobacterium violaceum CV026. Further tests using Escherichia coli JB523 showed that micro-algal extracts inhibited or stimulated quorum sensing, depending on the algal strain. One freshwater and five marine algae showed quorum sensing inhibitory activity, whereas two algae stimulated quorum sensing-regulated gene expression. Micro-algal strains that showed inhibitory activity in the previous assays also inhibited acylhomoserine lactone-regulated bioluminescence in the aquaculture pathogen Vibrio harveyi. The growth of all reporter strains was found to be unaffected by the micro-algal samples. The most promising micro-algal strain was found to be Chlorella saccharophila CCAP211/48, as its extracts inhibited quorum sensing-regulated gene expression in all three reporter strains. (C) 2011 Elsevier B.V. All rights reserved.
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