Journal
INFECTION AND IMMUNITY
Volume 72, Issue 6, Pages 3674-3679Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.72.6.3674-3679.2004
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Funding
- NHLBI NIH HHS [HL59842, R01 HL059842] Funding Source: Medline
- NIAID NIH HHS [AI33774, R37 AI033142, R01 AI033774, R01 AI033142, AI33142] Funding Source: Medline
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Cryptococcus neoformans releases capsular polysaccharide in the supernatant of liquid cultures and in tissues. Significantly less glucuronoxylomannan (GXM) was released by C neoformans in the presence of capsule-binding monoclonal antibody (MAb). MAb-mediated inhibition of GXM release may be another mechanism by which humoral immunity can mediate protection against this pathogen.
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