Journal
RESEARCH IN NURSING & HEALTH
Volume 27, Issue 3, Pages 174-184Publisher
WILEY
DOI: 10.1002/nur.20019
Keywords
cancer cachexia; P7016k; mice; indomethacin; ibuprofen; ubiquitin-conjugated; proteins; colon-26 adenocarcinoma; muscle wasting; western blotting
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Skeletal muscle wasting is a prominent feature of cancer cachexia and involves decreased muscle protein synthesis and increased activity of the ubiquitin-proteasome pathway of protein degradation. We report that both indomethacin and ibuprofen improved body weight and weight of the gastrocnemius muscle in tumor-bearing mice. Ibuprofen increased the soluble protein content of the muscle without affecting muscle levels of phosphorylated p70 S6 kinase, a ribosomal kinase involved in protein synthesis. Paradoxically, indomethacin increased levels of ubiquitin-conjugated proteins. Further study is needed to understand the mechanism of action by which indomethacin and ibuprofen preserve body weight and muscle mass in the tumor-bearing mice. The data suggest that ibuprofen may have beneficial effects in the treatment of cancer cachexia. (C) 2004 Wiley Periodicals, Inc.
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