Journal
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
Volume 10, Issue 3, Pages 134-137Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.rhu.0000128856.13595.eb
Keywords
amyloidosis; familial Mediterranean fever (FMF); infliximab; proteinuria
Categories
Ask authors/readers for more resources
We describe a patient with a long history of familial Mediterranean fever who developed proteinuria as a result of secondary AA amyloidosis. In this patient, the inflammatory process, including recurrent attacks of arthritis, abdominal pain, nephrotic syndrome secondary to amyloidosis, and high sedimentation rate, was rapidly suppressed by treatment with infliximab and there was remarkable improvement of the proteinuria. Because TNF-alpha is a proinflammatory cytokine that plays a major role in FMF and secondary amyloid, it is an appropriate target for therapy. Our case is the first case of reactive systemic amyloidosis secondary to familial Mediterranean fever, which responded favorably to infliximab.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available