Journal
JOURNAL OF VIROLOGY
Volume 78, Issue 12, Pages 6688-6691Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.78.12.6688-6691.2004
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Funding
- NIAID NIH HHS [AI 35602, AO 50709-02A1, R01 AI035602, R01 AI050709] Funding Source: Medline
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Utilizing a human cytomegalovirus-specific fusion inhibitor and an antiglycoprotein H antibody, we studied the role of virion fusion in interferon-stimulated gene (ISG) induction. Our results indicate that ISG induction does not occur when virion-mediated, post-high-affinity attachment events are inhibited by either reagent. Thus, virion-mediated postattachment events, such as fusion, are required for ISG induction.
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