Journal
MOLECULAR MICROBIOLOGY
Volume 52, Issue 6, Pages 1531-1541Publisher
WILEY
DOI: 10.1111/j.1365-2958.2004.04056.x
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Funding
- FIC NIH HHS [TW01594] Funding Source: Medline
- NIAID NIH HHS [AI30060, 5F32AI10044, 5T32AI07404] Funding Source: Medline
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The club-shaped rhoptries in Apicomplexan parasites are one of the most unusual secretory organelles among the eukaryotes, containing unusual lipid and protein cargo that is specialized for intracellular parasitism. Rhoptries have traditionally been viewed strictly as regulated secretory granules. We discuss in this article recent data on the cargo, function and biogenesis of rhoptries in two parasitic model systems, Toxoplasma and Plasmodium. Current findings suggest that rhoptries receive products from both biosynthetic and endocytic pathways and, therefore, they are most analogous to secretory lysosomal granules found in mammalian cells.
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