Journal
ANNALS OF NEUROLOGY
Volume 55, Issue 6, Pages 879-883Publisher
WILEY
DOI: 10.1002/ana.20121
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Funding
- NINDS NIH HHS [P01 NS16375] Funding Source: Medline
- PHS HHS [M01-4400052] Funding Source: Medline
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Evidence suggests early structural brain changes in individuals with the Huntington's disease (HD) genetic mutation who are presymptomatic for the movement symptoms of the illness. The aim of this study was to investigate the presence of functional brain changes in this same population using functional magnetic resonance imaging. Subjects and matched controls underwent an functional magnetic resonance imaging interference protocol, a task known to be mediated in part by corticostriatal circuitry. In the setting of normal cognitive performance, presymptomatic HD subjects had significantly and specifically less activation in the left anterior cingulate cortex (BA 24, 32) compared with matched controls.
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