Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 39, Issue 6, Pages 527-533Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2004.02.005
Keywords
piperidin-4-one; cyanoethylation; benzoxazole; antibacterial activity; antifungal activity
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Some novel benzoxazolyletboxypiperidones have been synthesized and their antibacterial activity against streptococcus faccalis, bacillus subtilis, escherichia coli, staphylococcus aureus aand pseudomonas aeruginosa and antifungal activity against Candida-6, Candida albicans, Aspergillus niger, Candida-51 and Aspergillus flavus were evaluated. Compounds 37, 38 and 39 exerted potent in vitro antibacterial activity against Streptococcus faecalis while compounds 40 and 41 exhibited potent in vitro antifungal activity against Candida-51. (C) 2004 Elsevier SAS. All rights reserved.
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