Journal
IUBMB LIFE
Volume 56, Issue 6, Pages 349-354Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15216540412331286002
Keywords
Alzheimer's disease; microarray; aging; interferon-induced; protein 3; beta amyloid
Categories
Ask authors/readers for more resources
The purpose of this study was to investigate gene expression in Alzheimer's disease ( AD), the most common form of senile dementia. We utilized the microarray technology to simultaneously compare the expression pro. le of 12,000 human genes in cerebral cortex of AD and normal aging. To identify gene expression related to neurodegeneration, beside the presence of amyloid deposition, we used control brains with abundant amyloid plaques, derived from cognitively normal elderly subjects. The microarray analysis indicated that 314 genes were differentially expressed in AD cerebral cortex, with differences greater than 5 folds in 25 genes. RT-PCR performed on a selected group of genes confirmed the increased expression of the interferon-induced protein 3 in AD brain. This protein, which is highly inducible by both type I and type II interferons, was not previously associated with the neurodegenerative disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available