Journal
CLINICA CHIMICA ACTA
Volume 344, Issue 1-2, Pages 109-114Publisher
ELSEVIER
DOI: 10.1016/j.cccn.2004.02.008
Keywords
purine nucleoside phosphorylase; plasma; HPLC method; cancer
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Background: Purine nucleoside phosphorylase (PNP) is the purine salvage enzyme that converts guanosine to guanine and inosine to hypoxanthine. Methods: 279 samples from patients with differing cancers were collected during treatment at both pre- and post-dose stages for plasma PNP activity and compared with a normal population. Results: Normal plasma PNP activity was found to be 3.2 +/- 1.4 U/l (n = 55) as compared with the cancer patients (pre-dose 12.3 +/- 7.4 U/l [n = 215] and post-dose 11.2 +/- 5.9 U/l [n = 64]). Levels of plasma PNP did not differ greatly between the different cancer types but were on average four times greater than that found in the reference population. (C) 2004 Elsevier B.V. All rights reserved.
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