Journal
JOURNAL OF IMMUNOLOGY
Volume 172, Issue 11, Pages 6533-6537Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.172.11.6533
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Funding
- NHLBI NIH HHS [HL-63925, HL-69502] Funding Source: Medline
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The relative contributions of CD62L(high) (central) memory and CD62L(low) (effector) memory T cell populations to recall responses are poorly understood, especially in the respiratory tract. In this study, we took advantage of a dual-adoptive transfer system in the mouse to simultaneously follow the recall response of effector and central memory subpopulations to intranasal parainfluenza virus infection. Using MHC class I and class II multimers, we tracked the responses of Ag-specific CD8(+) and CD4(+) memory T cells in the same animals. The data show that effector memory T cells mounted recall responses that were equal to, or greater than, those mounted by central memory T cells. Moreover, effector memory T cells were more efficient at subsequently establishing a second generation of memory T cells. These data contrast with other studies indicating that central memory CD8(+) T cells are the prominent contributors to systemic virus infections.
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