Journal
SEMINARS IN NEUROLOGY
Volume 24, Issue 2, Pages 197-204Publisher
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-2004-830907
Keywords
insecticides; organophosphate poisoning; intermediate syndrome; neuropathy; extrapyramidal parkinsonism; paralysis; neurobehavioral
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Organophosphates are commonly used as pesticides around the world. Exposures to organophosphates cause a significant number of poisonings and deaths each year. Organophosphates bind and inhibit cholinesterase enzymes. Acute toxicity manifests as a cholinergic crisis with excessive glandular secretions, altered mental status, and weakness. Several delayed syndromes have also been associated with organophosphate exposure, including a myasthenic-like syndrome, peripheral neuropathies, neuropsychiatric abnormalities, and extrapyramidal disorders. Clinical features and management of organophosphate poisoning is reviewed with emphasis on those affecting the central and peripheral nervous system.
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