Journal
CARBOHYDRATE RESEARCH
Volume 339, Issue 8, Pages 1467-1473Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2004.03.017
Keywords
Staphylococcus epidermidis; teichoic acid; alanine; biofilm
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The ability to adhere to artificial surfaces and form biofilms is considered as a virulence factor of Staphylococcus epidermidis, one of the major causes of nocosomial infections, especially those related to implanted medical devices. Cell-wall teichoic acid is known to play an important role in biofilm formation of staphylococci. The structure of the cell wall and extracellular teichoic acids of S. epidermidis RP62A, a reference biofilm-positive strain, was studied by NMR spectroscopy and capillary electrophoresis-mass spectrometry. Their structures were found to be a (1 --> 3)-linked poly(glycerol phosphate), substituted at the 2-position of glycerol residues with alpha-Glc, alpha-GlcNAc, D-Ala and alpha-Glc6AIa. D-Alanyl acylation of a sugar hydroxyl group seems to be a novel structural feature of teichoic acids from staphylococci. (C) 2004 Elsevier Ltd. All rights reserved.
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