Journal
ANNALS OF ONCOLOGY
Volume 15, Issue 6, Pages 875-884Publisher
OXFORD UNIV PRESS
DOI: 10.1093/annonc/mdh222
Keywords
body mass index; breast cancer; obesity; prognostic factor; survival
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Funding
- NCI NIH HHS [CA-75362] Funding Source: Medline
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Background: Current information on the prognostic importance of body mass index (BNH) for patients with early breast cancer is based on a variety of equivocal reports. Few have data on BMI in relationship to systemic treatment. Patients and methods: Patients (6792) were randomized to International Breast Cancer Study Group trials from 1978 to 1993, studying chemotherapy and endocrine therapy. BMI was evaluated with eight other factors: menopausal status, nodal status, estrogen receptor status, progesterone receptor status, tumor size, vessel invasion, tumor grade and treatment. BMI was categorized as normal (less than or equal to24.9), intermediate (25.0-29.9) or obese (greater than or equal to30.0). Results: Patients with normal BMI had significantly longer overall survival (OS) and disease-free survival (DFS) than patients with intermediate or obese BMI in pairwise comparisons adjusted for other factors. Subset analyses showed the same effect in pre- and perimenopausal patients and in those receiving chemotherapy alone. When assessed globally and adjusted for other factors, BMI significantly influenced OS (P = 0.03) but not DFS (P = 0. 12). \ Conclusions: BMI is an independent prognostic factor for OS in patients with breast cancer, especially among pre-/perimenopausal patients treated with chemotherapy without endocrine therapy.
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