Journal
GENES & DEVELOPMENT
Volume 18, Issue 11, Pages 1263-1271Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1198204
Keywords
epigenetics; chromatin; historic; Drosophila; chromatin immunoprecipitation microarray
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Funding
- NCI NIH HHS [R29 CA074841, CA74841, R01 CA074841] Funding Source: Medline
- NHLBI NIH HHS [HL57620] Funding Source: Medline
- NIDDK NIH HHS [R37 DK044746, DK44746] Funding Source: Medline
- NIGMS NIH HHS [GM43893, R01 GM043893] Funding Source: Medline
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The covalent modification of nucleosomal histones has emerged as a major determinant of chromatin structure and gene activity. To understand the interplay between various histone modifications, including acetylation and methylation, we performed a genome-wide chromatin structure analysis in a higher eukaryote. We found a binary pattern of histone modifications among euchromatic genes, with active genes being hyperacetylated for H3 and H4 and hypermethylated at Lys 4 and Lys 79 of 113, and inactive genes being hypomethylated and deacetylated at the same residues. Furthermore, the degree of modification correlates with the level of transcription, and modifications are largely restricted to transcribed regions, suggesting that their regulation is tightly linked to polymerase activity.
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