Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 16, Issue 3, Pages 263-271Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2004.04.004
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- NIGMS NIH HHS [GM-37120] Funding Source: Medline
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Considerable advances into the basis of RNA-polymerase-II-mediated transcriptional regulation have recently emerged. Biochemical, genetic and structural studies have contributed to novel insights into transcription, as well as the functional significance of covalent histone modifications. New details regarding transcription elongation through chromatin have further defined the mechanism behind this action, and identified how chromatin structure may be maintained after RNAP II traverses a nucleosome. ATP-dependent chromatin remodeling complexes, along with histone chaperone complexes, were recently discovered to facilitate histone exchange. In addition, it has become increasingly clear that transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm.
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