Journal
PEPTIDES
Volume 25, Issue 6, Pages 941-950Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2004.03.005
Keywords
protease inhibitor; peptide family; real-time PCR; gene expression; Schistocerca gregaria; cuticle; entomopathogenic fungus
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Recently, a new serine protease inhibitor family has been described in arthropods. Eight members were purified from locusts and 13 peptides have been identified by cDNA cloning. The peptides share a conserved cysteine array (Cys-Xaa(9-12)-Cys-Asn-Xaa-Cys-Xaa-CysXaa(2-3)-Gly-Xaa(3-6)-Cys-Thr-Xaa(3)-Cys) with nine inhibitory domains (PLDs) of the light chain of the crayfish protease inhibitor, pacifastin. A molecular identification of a pacifastin-related precursor (SGPP-5) with three novel PLD-related peptides is presented in this study. This is a first report, identifying the presence of a SGPP-transcript in the brain, fore- and hindgut, including a 100-fold difference in fat body SGPP-transcript level of male as compared with female locust. (C) 2004 Elsevier Inc. All rights reserved.
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