Journal
JOURNAL OF NEUROBIOLOGY
Volume 59, Issue 3, Pages 261-271Publisher
WILEY
DOI: 10.1002/neu.10311
Keywords
Pycnogenol; vitamin E; ethanol; apoptosis; oxidative stress
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Funding
- NIAAA NIH HHS [AA07561, AA12151] Funding Source: Medline
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Pycnogenol(R) (PYC), a patented combination of bioflavonoids extracted from the bark of French maritime pine (Pinus maritima), scavenges free radicals and promotes cellular health. The protective capacity of PYC against ethanol toxicity of neurons has not previously been explored. The present study demonstrates that in postnatal day 9 (P9) rat cerebellar granule cells the antioxidants vitamin E (VE) and PYC (1) dose dependently block cell death following 400, 800, and 1600 mg/dL ethanol exposure (2) inhibit the ethanol-induced activation of caspase-3 in the same model system; and (3) reduce neuronal membrane disruption as assayed by phosphatidylserine translocation to the cell surface. These results suggest that both PYC and VE have the potential to act as therapeutic agents, antagonizing the induction of neuronal cell death by ethanol exposure. (C) 2004 Wiley Periodicals, Inc.
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