Journal
ACCOUNTS OF CHEMICAL RESEARCH
Volume 37, Issue 6, Pages 365-377Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ar030245r
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Funding
- NCI NIH HHS [CA 19033, CA 70329] Funding Source: Medline
- NIGMS NIH HHS [GM 29028] Funding Source: Medline
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Umpolung-based strategies play a significant role in organic synthesis. Particularly important are 1,3-dithiane linchpins, which serve as convenient acyl anion equivalents. The general synthetic accessibility and impressive reactivity of 1,3-dithianes have thus led to widespread application. Since the late 1970s, dithianes have featured prominently in our program directed toward the synthesis of complex natural and unnatural products, both for effective union of advanced fragments and for multicomponent linchpin couplings. In this Account, we present the evolution of dithiane chemistry in our laboratory.
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