Journal
GENOMICS
Volume 83, Issue 6, Pages 1176-1178Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygeno.2003.12.014
Keywords
D6Slab17; grid; ionotropic glutamate receptor; paralogous; Parkinson's disease; hemostasis; Emilin
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A deletion of the murine Snca gene has been discovered in C57BL/6JOlaHsd. a population of the inbred strain C57BL/6J. We now characterize the exact nature of this deletion, Del(6)Snca I Slab. Detailed mapping and sequencing of the breakpoint revealed the absence of 365 kb, encompassing the Mmrn1 gene in addition to Snca. Despite the lack of alpha-synuclein and multimerin-1 C57BL/6JOlaHsd animals do not display obvious phenotypes. Sequence comparisons revealed that the chromosomal organization of Sncg and Mmrn2 is highly reminiscent of the region containing Snca and Mmrn1, suggesting a duplication event of a cluster of apparently unrelated genes during evolution. (C) 2004 Elsevier Inc. All rights reserved.
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