Journal
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
Volume 130, Issue 6, Pages 307-319Publisher
SPRINGER
DOI: 10.1007/s00432-003-0530-y
Keywords
angiogenesis; hepatocellular carcinoma
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Hepatocellular carcinoma (HCC) is a typical hypervascular tumor. Many angiogenic factors have been studied in HCC, and several anti-angiogenic therapies have been tested in animal models and patients. This paper summarizes the latest findings, especially regarding the clinical significance of endothelial cell markers and angiogenic factors in HCC, and experimental and clinical anti-angiogenesis therapies. Further developments in this area, such as endothelial cell-oriented research and better experimental and clinical designs in the evaluation of anti-angiogenic therapies are discussed.
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