Journal
SEMINARS IN CANCER BIOLOGY
Volume 14, Issue 3, Pages 195-200Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2003.10.006
Keywords
CXC chemokines; angiogenesis; tumor growth; cancer
Categories
Funding
- NCI NIH HHS [CA87879, P50 CA90388] Funding Source: Medline
- NHLBI NIH HHS [P50 HL67665, HL66027, HL04493] Funding Source: Medline
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The CXC chemokine family are unique cytokines known for their ability to have dual functions in the regulation of angiogenesis related to the following: (1) the presence or absence of the structural/functional motif (Glutamic acid-Leucine-Arginine; 'ELR' motif) that immediately precedes the first cysteine amino acid residue in the primary structure of these chemokines; (2) interferon-inducible gene expression; and (3) specific receptor interaction on endothelial cells. In this review we will appraise the biology of these angiogenic and angiostatic CXC chemokines, and discuss their disparate angiogenic activity in the context of the pathogenesis of cancer. (C) 2003 Elsevier Ltd. All rights reserved.
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