Journal
INSECT MOLECULAR BIOLOGY
Volume 13, Issue 3, Pages 273-282Publisher
WILEY
DOI: 10.1111/j.0962-1075.2004.00484.x
Keywords
Armigeres subalbatus; pattern recognition receptor; mosquito; lectin; innate immunity; haemocyte
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Funding
- NIAID NIH HHS [AI 50252, AI 19769] Funding Source: Medline
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Mosquitoes have an efficient cellular innate immune response that includes phagocytosis of microbial pathogens and encapsulation of metozoan parasites. In this study, we describe a novel lectin in the mosquito, Armigeres subalbatus (aslectin or AL-1). The 1.27 kb cDNA clone for the AL-1 gene (AL-1) encodes a 279 deduced amino acid sequence that contains a C-terminal fibrinogen-like domain. AL-1 is transcribed in all life stages. AL-1 mainly exists in the haemolymph of adult female mosquitoes, and is upregulated following both Escherichia coli and Micrococcus luteus challenge. AL-1 specifically recognizes N-acetyl-D-glucosamine and is able to bind both E. coli and M. luteus. These results suggest that AL-1 might function as a pattern recognition receptor in the immune response in Ar. subalbatus.
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