Journal
DEVELOPMENTAL DYNAMICS
Volume 230, Issue 2, Pages 210-215Publisher
WILEY
DOI: 10.1002/dvdy.20042
Keywords
sex determination; ovary; coelomic vessel; germ cells; follistatin; Wnt4
Categories
Funding
- NCI NIH HHS [CA09541] Funding Source: Medline
- NICHD NIH HHS [HD32067, R01 HD039963] Funding Source: Medline
- PHS HHS [HE39963] Funding Source: Medline
Ask authors/readers for more resources
Wnt4(-/-) XX gonads display features normally associated with testis differentiation, suggesting that WNT4 actively represses elements of the male pathway during ovarian development. Here, we show that follistatin (Fst) which encodes a TGFbeta superfamily binding protein, is a downstream component of Wnt signaling. Fst inhibits formation of the XY-specific coelomic vessel in XX gonads. In addition, germ cells in the ovarian cortex are almost completely lost in both Wnt4 and Fst null gonads before birth. Thus, we propose that WNT4 acts through FST to regulate vascular boundaries and maintain germ cell survival in the ovary. (C) 2004 Wiley-Liss, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available