Journal
SEMINARS IN CANCER BIOLOGY
Volume 14, Issue 3, Pages 181-185Publisher
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2003.10.004
Keywords
chemokines; cancer; metastasis; CXCR4; CCR7
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Chemokines and their receptors have emerged as attractive targets regulating the migration of tumor cells in vivo, a process known as cancer metastasis. The control of metastasis is critical to the control of cancer progression. Two chemokine receptors and their ligands stand out as likely targets for therapeutics: CCR7/CCL21 for lymph node metastases, and CXCR4/CXCL12 for lung, liver, bone marrow, and brain metastases. The most widely expressed chemokine receptor among cancers is likely to be CXCR4. (C) 2003 Published by Elsevier Ltd.
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