Journal
PEDIATRIC ALLERGY AND IMMUNOLOGY
Volume 15, Issue 3, Pages 242-246Publisher
WILEY
DOI: 10.1111/j.1399-3038.2004.00140.x
Keywords
interleukin-10; 25-hydroxyvitamin D; 1,25-dihydroxyvitamin D; total IgE; allergy
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The cytokine interleukin-10 (IL-10) plays a pivotal regulatory role in tolerizing exogenous antigens. Experimental data indicate that low cellular availability of the vitamin D hormone 1,25-dihydroxyvitamin D [1,25(OH)(2)D] results in a down-regulation of IL-10 concentrations. The tissue production of an adequate amount of 1,25(OH)(2)D depends on a high circulating 25-hydroxyvitamin D (25-OHD) level. The present study was thus aimed at evaluating the associations between season of birth, vitamin D status, and the allergy risk markers IL-10 and total immunoglobulin (IgE) in newborns. Cord blood was obtained from 49 infants born during the summer half year (mid-April to mid-October, geographic latitude 51degreesN) and from 47 infants born during the winter half year (mid-October to mid-April, geographic latitude of 51degreesN). Serum levels of 25-OHD were 99% higher, and IL-10 levels were 43% higher in the summer half year compared with the winter half year (p < 0.001 and p = 0.018). Moreover, the ratio of IL-10 to total IgE was 124% higher in the summer half year compared with the winter half year (p = 0.039). Serum levels of 25-OHD were correlated with IL-10 levels (r = +0.22; p < 0.05). Mothers' age, gestational ages, birth weights and serum 1,25(OH)(2)D levels did not differ between study groups. We conclude that the low vitamin D status of infants born in winter may at least in part adversely affect biomarkers of allergy risk.
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