Journal
BRAIN RESEARCH
Volume 1010, Issue 1-2, Pages 81-86Publisher
ELSEVIER
DOI: 10.1016/j.brainres.2004.02.064
Keywords
bcl-2; atypical antipsychotic drug; frontal cortex; hippocampus; in situ hybridization; western blot
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To investigate whether atypical antipsychotic drugs exert an effect on the neuroprotective protein Bcl-2, rats were chronically treated with clozapine or olanzapine for 28 days. The expression of bcl-2 mRNA and Bcl-2 protein was determined, respectively, by in situ hybridization in tissue sections and Western blot on tissue samples from rat frontal cortex and hippocampus. The bcl-2 mRNA positive cells were increased in these regions after drug treatments, and quantitative analysis revealed that the upregulation of bcl-2 mRNA and Bcl-2 protein is significantly greater than in vehicle control (p < 0.05 or p < 0.01). It is demonstrated that neuroprotective protein Bcl-2 is involved in the action of atypical antipsychotic drugs, and might represent a neuroprotective mechanism of these drugs. (C) 2004 Elsevier B.V All rights reserved.
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