Journal
NEUROREPORT
Volume 15, Issue 8, Pages 1225-1229Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.wnr.0000127636.15181.c1
Keywords
erythropoietin; neurogenesis; suppressor of cytokine signaling 2
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Funding
- NHLBI NIH HHS [R01HL 64766] Funding Source: Medline
- NINDS NIH HHS [P01 NS42345, P01NS23393, R01NS43324] Funding Source: Medline
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We examined the effects of EPO on expression of suppressor of cytokine signaling 2 (SOCS2) and found that treatment of neural progenitor cells derived from the adult subventricular zone (SVZ) with recombinant human EPO (rhEPO) stimulated progenitor cell differentiation into neurons, but not astrocytes. Quantitative RT-PCR revealed that SOCS2 mRNA levels were increased in the progenitor cells treated with rhEPO. Immunostaining showed that neurons but not astrocytes were SOCS2 immunoreactive. Incubation of the progenitor cells with rhEPO in the presence of a neutralizing antibody against EPO abolished the effects of EPO on neuronal differentiation and expression of SOCS2. Our data suggest that up-regulation of SOCS2 in neuronal progenitor cells derived from the adult SVZ may regulate EPO enhanced neuronal differentiation.
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