Dynamic kinetic resolution:: an efficient route to anti α-amino-β-hydroxy esters via Ru-SYNPHOS® catalyzed hydrogenation

The Ru(II)-catalyzed hydrogenation of alpha-amino-beta-keto esters as their hydrochloride salts affords preparation of the corresponding anti alpha-amino-beta-hydroxy esters under mild conditions with high diastereoselectivities and enantioselectivities via dynamic kinetic resolution.