Journal
JOURNAL OF NEUROSCIENCE
Volume 24, Issue 23, Pages 5292-5300Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0195-04.2004
Keywords
dopamine receptor; InsP3 receptor; subsurface cistern; electron microscopy; neuronal calcium; microdomain; prefrontal cortex; working memory
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Funding
- NIMH NIH HHS [MH44866] Funding Source: Medline
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The explicit yet enigmatic involvement of dopamine in cortical physiology is in part volumetric (beyond the synapse), as is apparently the action of neuroleptics targeting dopamine receptors. The notion that nonsynaptic neuronal membranes would translate extracellular dopamine into receptor-specific spatiotemporal downstream signaling, similar to the chemical synapse, is intriguing. Here, we report that dopamine D-5 (but not D-1 or D-2) receptors in the perisomatic plasma membrane of prefrontal cortical neurons form discrete and exclusively extrasynaptic microdomains with inositol 1,4,5-trisphosphate-gated calcium stores of subsurface cisterns and mitochondria. These findings introduce a novel dopaminoceptive substratum in the brain and a unique D-5 receptor-specific signaling paradigm.
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